Nucleofill Strong Plus is a next-generation polynucleotide (PN) injectable designed to address complex skin aging concerns through deep-level bioregeneration. Its formulation is based on high molecular weight polynucleotides derived through a highly purified biotechnology process, enabling the product to deliver exceptional bioactive performance in aesthetic medical treatments. As regenerative aesthetics continue to evolve, Nucleofill Strong Plus stands as one of the most scientifically validated biostimulating injectables available for professional use.

What sets Nucleofill Strong Plus apart is its multi-layered mechanism of action. Rather than functioning as a simple hydrating skin booster, its PN structures actively stimulate the skin’s natural regeneration pathways. The polynucleotides bind water, creating a strong hydrating matrix that supports optimal cellular activity. Concurrently, they promote fibroblast proliferation, increasing collagen type I and III production, improving extracellular matrix density, and enhancing overall skin structure.

This treatment is particularly effective for patients presenting with advanced signs of ageing such as volume loss, deep dehydration, reduced firmness, and impaired skin quality. By improving tissue oxygenation, reducing oxidative stress, and supporting DNA repair processes, Nucleofill Strong Plus offers a clinically robust solution suitable for medical aesthetic practitioners who prioritise regenerative outcomes over surface-level correction.

The product’s high-viscosity PN composition ensures sustained biostimulation over a longer period compared to typical skin boosters. This makes it ideal for deep dermal treatments where enhanced elasticity and structural reinforcement are primary concerns. Clinics relying on evidence-based protocols appreciate its ability to deliver long-term improvements without altering facial identity, making it a preferred option for patients seeking natural yet highly effective rejuvenation.

Nucleofill Strong Plus can be integrated into treatment plans for mid-face regeneration, advanced anti-aging therapies, and combination approaches involving polynucleotides, PRP, or energy-based devices. Because of its powerful tissue-healing capabilities, it is also used in treatments for post-inflammatory skin damage, photodamage, and environmental stress-induced degradation of the dermis.

From an operational standpoint, the injection process is straightforward for trained medical aesthetic professionals. Administered using linear threading, micro-bolus, or cannula techniques, Nucleofill Strong Plus adapts well to various clinical preferences. Its safety profile is excellent due to the high purity of the PN extract, and adverse reactions are minimal when used according to aesthetic medical standards.

As demand grows for regenerative rather than corrective treatments, Nucleofill Strong Plus has become a valuable addition to clinic portfolios. It supports practitioners in delivering long-lasting anti-aging outcomes, structural reinforcement, hydration, and improved dermal function—making it a standout choice in the category of polynucleotide biostimulators.

Treatment Areas

• Mid-face (cheeks, zygomatic region)

• Lower face (jawline definition, marionette zone)

• Neck

• Décolletage

• Areas with tissue laxity requiring deep regeneration

• Patients with moderate to severe photoaged skin

Usage

Administer via micro-bolus or linear-thread injection technique into the deep dermis or subcutaneous layer, depending on the treatment objective. A standard protocol typically includes 2–3 treatment sessions spaced 2–4 weeks apart. Only to be used by trained medical aesthetic practitioners. Suitable as a standalone treatment or in regenerative combination therapy.

Ingredient List & Description

Polynucleotides (PN) – High Molecular Weight

• Volume: 2.0–2.5ml (dependent on manufacturer specification)
  Polynucleotides provide hydration, stimulate fibroblasts, support collagen production, improve dermal density, and enhance tissue regeneration. They also promote antioxidant protection and cellular repair.

Product Dimensions / Size

1 x pre-filled syringe
Volume: 2–2.5ml (confirm per supplier batch)

Product Duration

Results typically last 6–12 months, depending on patient lifestyle, age, and tissue quality. Biostimulation continues over time due to the regenerative nature of polynucleotides.

Manufactured By

Promoitalia Laboratories
 

5 Popular Questions and Answers:

1. What is Nucleofill Strong Plus used for?

Nucleofill Strong Plus is primarily used for deep dermal regeneration, improving skin firmness, elasticity, hydration, and cellular repair. It is ideal for patients with moderate to severe skin laxity, photoaging, or compromised dermal structure. It works by stimulating fibroblasts, enhancing collagen production, and restoring the extracellular matrix. The treatment is suitable for mid-face rejuvenation, neck tightening, and improving overall skin density.

2. How does Nucleofill Strong Plus differ from standard skin boosters?

Unlike hyaluronic acid skin boosters, Nucleofill Strong Plus uses high molecular weight polynucleotides that activate regenerative pathways. It doesn’t simply hydrate the skin—it triggers fibroblast activation, improves tissue oxygenation, and enhances dermal architecture. This makes it more effective for long-term anti-aging and structural improvement.

3. How many sessions are recommended?

Most patients require 2–3 sessions spaced 2–4 weeks apart. Severe aging may benefit from additional maintenance sessions throughout the year.

4. Is Nucleofill Strong Plus safe?

Yes. Due to its highly purified PN composition, the product has an excellent safety profile. Side effects are mild and typically limited to temporary redness or swelling.

5. How long do results last?

Results typically last 6–12 months. The regenerative effects continue over time due to the product’s biostimulating action, offering long-term improvement in dermal quality.