Plenhyage XL Strong

Plenhyage XL Strong 1 x 2ml is an advanced regenerative injectable treatment formulated with highly purified polynucleotides (PN) to target skin aging, atrophy, and laxity. Developed by Regenyal Laboratories (Italy), this bio-restructuring product is designed for aesthetic professionals seeking powerful and scientifically backed skin regeneration solutions.

Unlike conventional hyaluronic acid (HA) boosters, Plenhyage XL Strong acts at a cellular level—stimulating fibroblasts, improving tissue oxygenation, and accelerating dermal regeneration. Polynucleotides are natural DNA fragments that enhance cell metabolism, hydrate the extracellular matrix, and promote neocollagenesis (new collagen formation).

Mechanism of Action:

Once injected, the PN molecules bind water molecules, deeply hydrating the dermis while neutralising free radicals and oxidative stress. This process provides an ideal environment for fibroblast proliferation and tissue biorestructuring.
The result is visibly firmer, denser, and rejuvenated skin with long-term improvement in tone and elasticity.

Clinical Benefits:

• Restores dermal density and firmness in aging or sun-damaged skin

• Stimulates fibroblast activity for collagen and elastin regeneration

• Improves hydration and dermal elasticity

• Reduces deep wrinkles and skin sagging

• Repairs tissue damage following inflammation, scarring, or laser procedures

• Provides antioxidant protection and cell renewal

Plenhyage XL Strong is recommended for moderate to advanced photoaging, loss of dermal thickness, or post-procedure skin recovery. It is particularly effective on the face, neck, décolletage, and hands, providing both corrective and preventive anti-aging benefits.

Clinical Protocol:

• 2–4 sessions, spaced 2–3 weeks apart

• Maintenance session every 6 months, depending on skin condition and age

• Injectable using microinjections, linear, or retrograde threading techniques into the mid to deep dermis

Treatment Areas:

• Face (including cheeks, perioral, and periorbital areas)

• Neck

• Décolletage

• Hands

• Atrophic and photoaged skin

• Areas requiring firming and tightening

Usage:

Administered by licensed medical professionals using microinjection or cannula technique. Ideal as a standalone treatment or in combination with other regenerative therapies, skin boosters, or chemical peels to enhance overall rejuvenation.

Recommended treatment protocol:

• 2–4 sessions every 2–3 weeks

• Maintenance every 6–9 months

Ingredient List:

• Polynucleotides (PN): 20 mg/ml – purified DNA fragments of natural origin that promote fibroblast activity, collagen synthesis, and tissue regeneration.

• Buffer Solution: Maintains isotonicity and pH balance for safe and comfortable injections.

• Water for Injection: Ensures sterility and purity.

Product Dimensions / Size:

• 1 x 2ml prefilled syringe per box

• Needles not included

• Sterile, single-use

Product Duration:

Visible results appear after the first treatment and continue to improve over several weeks.
Duration of effects: Approximately 9–12 months, depending on the patient’s age, skin quality, and lifestyle.

Popular Questions & Answers

1. What is Plenhyage XL Strong used for?
Plenhyage XL Strong is used to treat moderate to severe skin laxity, wrinkles, and dermal thinning through deep regenerative stimulation using purified polynucleotides.

2. How does Plenhyage XL Strong differ from Plenhyage Medium?
The Strong version contains a higher PN concentration (20 mg/ml) and is intended for more mature, photoaged, or atrophic skin, while Medium is suited for early signs of aging.

3. How long do results last?
Results typically last 9–12 months, with continued improvement due to collagen remodeling and fibroblast activation after treatment sessions.

4. Can Plenhyage Strong be used with other treatments?
Yes, it can be safely combined with HA fillers, mesotherapy, chemical peels, microneedling, and PRP to enhance regenerative and aesthetic outcomes.

5. Is Plenhyage Strong suitable for all skin types?
Yes. Plenhyage is biocompatible, CE-marked, and clinically tested, making it suitable for all skin types, including sensitive and mature skin.