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<\/figure>\n\n\n\nWhat Are Polynucleotides and Where Do They Come From?<\/h2>\n\n\n\n
Polynucleotides are long chains of nucleotides, the basic building blocks of DNA. In aesthetic medicine, they’re derived from highly purified salmon or trout DNA (depending on the manufacturer), which shares a significant structural similarity with human DNA. That similarity is part of what makes them so well tolerated and clinically effective.<\/p>\n\n\n\n
The concept isn’t new. Polynucleotides have been used in wound healing and ophthalmology for decades. What’s relatively new is their application in aesthetic medicine, and the pace at which the evidence base has grown over the last few years has been genuinely impressive.<\/p>\n\n\n\n
They work differently from anything else in your kit. They don’t add volume. They don’t fill. They stimulate. The mechanism of action is centred on fibroblast activation, cellular repair, and tissue regeneration. In practical terms, that means improved skin quality from the inside out, not a surface-level fix.<\/p>\n\n\n\n
The Science Behind PDRN and Why It Matters Clinically<\/h2>\n\n\n\n
You’ll hear polynucleotides referred to interchangeably with PDRN (polydeoxyribonucleotide)<\/strong>, and while there are technical distinctions between them depending on molecular weight and purification method, for the purposes of clinical practice the terms are broadly used to describe the same category of treatment.<\/p>\n\n\n\n PDRN treatment works primarily through two pathways. The first is the salvage pathway, where fragmented DNA is taken up by cells and used as raw material for tissue repair and regeneration. The second is through activation of A2A adenosine receptors, which triggers an anti-inflammatory response and promotes angiogenesis (the formation of new blood vessels). Better vascular supply means better tissue nutrition, which means healthier, more resilient skin over time.<\/p>\n\n\n\n This is what separates polynucleotides from standard hyaluronic acid skin boosters<\/mark><\/a>. You’re not just hydrating the tissue, you’re actually changing the cellular environment. For patients with chronically damaged, depleted, or ageing skin, that distinction matters enormously.<\/p>\n\n\n\n There are a growing number of polynucleotide products on the market now, and the quality varies. Plinest is one of the most clinically credible options available, and it’s worth understanding what sets it apart.<\/p>\n\n\n\n Plinest is manufactured by Mastelli, an Italian pharmaceutical company with a long track record in regenerative medicine. The product uses highly purified PDRN derived from Oncorhynchus mykiss (rainbow trout) DNA, which undergoes a rigorous extraction and sterilisation process to ensure purity and biocompatibility.<\/p>\n\n\n\n It’s available in different formulations designed for different clinical indications. Plinest Classic is the standard option for overall skin quality improvement. Plinest Eye is specifically formulated for the periorbital area, a notoriously difficult region to treat effectively with most injectables. And Plinest Fast contains a lidocaine addition for improved patient comfort during injection.<\/p>\n\n\n\n As a polynucleotide skin booster, Plinest sits in a slightly different category from pure HA products. It’s regenerative rather than purely hydrating, which means the results develop over time rather than being immediately visible. Set that expectation with your patients from the start.<\/p>\n\n\n\n If there’s one area where polynucleotides genuinely outperform most other treatments, it’s the periorbital region.<\/p>\n\n\n\n Polynucleotide under eyes treatment has become one of the most requested applications in clinics that offer it, and the results explain why. The skin under the eyes is thinner, more fragile, and more prone to showing the signs of ageing than almost anywhere else on the face. Traditional HA fillers in this area carry real risks (Tyndall effect, migration, puffiness) and require a level of precision that makes them unsuitable for many patients.<\/p>\n\n\n\n Polynucleotides approach the problem differently. Rather than adding volume, they improve the quality of the tissue itself. Patients with crepiness, dark circles related to skin thinning, and fine lines in the periorbital area often see significant improvement after a course of treatment. It’s not dramatic in the way a filler result is, but it’s often more appropriate, particularly for younger patients who don’t need volume but do need skin quality improvement.<\/p>\n\n\n\n Plinest Eye<\/mark><\/a> is specifically designed for this area, with a formulation optimised for the delicate periorbital tissue.<\/p>\n\n\n\n Read more about Plinest Eye here:<\/strong> Why Plinest Eye Is Trending in Aesthetic Treatments<\/mark><\/a><\/p>\n\n\n\nPlinest, The Polynucleotide Product Worth Knowing<\/h3>\n\n\n\n
Polynucleotide Under Eyes, One of the Best Applications in Practice<\/h2>\n\n\n\n